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Nitiloop's Innovation

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THE NEED 

Revascularization of Chronic Total Occlusions (CTO) is a primary challenge in both cardiovascular and peripheral procedures. Approximately 3.2 million cardiovascular disease (CVD) procedures were performed in 2019, of which 15-20% required CTO recanalization. In the peripheral artery disease (PAD) market, 1 million limb procedures were carried out.  One-third of the procedures were Below-the-Knee (BTK), and more than 50% of these cases required CTO revascularization.
 

The most commonly used technique for CTO is intraluminal revascularization using a guidewire and support microcatheter. Frequently however, the guidewire either cannot penetrate the proximal cap or pass through the occlusion.  In such cases, devices for subintimal approaches such as antegrade dissection or re-entry are used.   In the most complicated cases, retrograde approaches are implemented (or a combination of retrograde and antegrate methods).  

As the complexity of the procedure increases, procedure duration and costs increase, and greater operator skill is required. 

01 |

Intraluminal revascularization with guidewire and support microcatheter
 

The access of choice. Pushing the guidewire’s tip through the proximal cap is frequently ineffective.

02 |

Antegrade dissection/subintimal approaches
 

Require more skills, more procedure time, and are more expensive.

03 |

Retrograde approach with

antegrade dissection


More costly, time-consuming, and requires advanced skill.

Increased complexity, time and cost

An integrated microcatheter
that saves time and costs

NITILOOP'S 2-IN-1 SOLUTION 

Nitiloop has developed a proprietary technology that facilitates successful antegrade CTO procedures.  The technology has been clinically proven to yield high procedure success rates with low perforation rates.  Developed by a renowned cardiologist, Nitiloop's products enable all operators, even novice ones, to perform antegrade CTO procedures with greater precision, safety and efficacy. 

  • Expandable nitinol scaffold deployed  close to the lesion

  • Guidewire and tip have the force and precision necessary to penetrate the blockage

  • Scaffolding support does not damage the vessel's endothelial

  • Centered guidewire and microcatheter deliver safer and more predictable outcomes

  • Reduced risk of perforation

 

  • Scaffold can be repeatably closed and redeployed to allow catheter repositioning

An integrated microcatheter
that saves time and costs

  • Microcatheter follows the guidewire into the lesion and further opens the occluded area
     

  • Easy transition to the next stage of the procedure (balloon/stenting)

An anchoring mechanism for high-performance lesion penetration

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