Clinical Need: PAD CTO
Peripheral artery disease (PAD) is a progressive disorder characterized by stenosis and/or occlusion of large and medium-sized arteries, other than those that supply the heart (coronary artery disease, CAD) or the brain (cerebrovascular disease).
PAD affects the lower extremities more commonly than the upper extremity vessels. It frequently leads to recurrent fatigue, cramping sensations, or pain known as claudication intermittent (intermittent claudication), which is the most recognized symptomatic subset of lower extremity PAD.
It is estimated that >200 million people suffer from PAD worldwide, with symptoms ranging from none to severe. PAD has also been associated with increased risk for cardiovascular morbidity and mortality.
PAD is relatively uncommon among younger people but its prevalence increases with age. It is estimated that over 20% of people over the age of 80, suffer from some form of PAD. Approximately 50% of symptomatic patients will suffer from totally occluded arteries which will require re-canalization for further treatment.
Notwithstanding its widespread prevalence, PAD remains overall underdiagnosed and undertreated.